Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

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Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce is the kind of comforting, rich, and spicy dish that makes dinner feel like a treat. It’s the marriage of creamy cheese, a garlicky bite, and bold Cajun flavors, all wrapped around strands of tender spaghetti and juicy chicken. Whether you’re cooking for a weeknight dinner or looking to impress guests, this one checks every box.

What makes this pasta extra special is the sauce. A blend of cream, mozzarella, and roasted garlic creates a velvety coating that clings to each noodle. Paired with the smoky heat of Cajun seasoning and golden-seared chicken, this dish is hearty without being heavy, and spicy without being overpowering.

Why You’ll Love This Creamy Cajun Chicken Spaghetti

If you’re a fan of bold, zesty meals that deliver flavor in every bite, this recipe will quickly become a favorite. The richness of the cheese balances the spice, while garlic adds depth that makes the sauce crave-worthy. It’s an easy dinner with a gourmet touch that feels indulgent yet comes together effortlessly.

Plus, it’s customizable. You can dial the Cajun spice up or down, use different pasta shapes, or even toss in some veggies to make it your own. It’s a one-pan comfort food moment that everyone at the table will ask for again.

What Kind of Spaghetti or Pasta Should I Use?

Classic spaghetti works beautifully here, letting the creamy garlic mozzarella sauce coat every bite. But if you’re looking for alternatives, fettuccine or linguine can also work well, giving you more surface area for the sauce to cling to. For a twist, try rotini or penne – they catch the bits of chicken and cheese perfectly. Whichever you choose, make sure to cook it just to al dente so it holds up in the creamy sauce.

Ingredients for the Creamy Cajun Chicken Spaghetti

To bring out the full flavor of this indulgent pasta dish, you’ll want to choose ingredients that balance richness, spice, and texture. The creaminess comes from a decadent cheese sauce, while the Cajun seasoning offers a kick of heat that makes it unforgettable.

• Chicken breast
• Spaghetti
• Heavy cream
• Mozzarella cheese
• Parmesan cheese
• Garlic cloves
• Butter
• Olive oil
• Cajun seasoning
• Salt
• Black pepper
• Paprika
• Parsley
• Chicken broth

Each of these ingredients plays a role: the chicken breast is seared for a golden crust; spaghetti forms the base; heavy cream, mozzarella, and parmesan create a rich, cheesy sauce. Garlic, butter, and olive oil add depth, while Cajun seasoning, paprika, salt, and black pepper deliver the flavor punch. Parsley adds a pop of freshness, and chicken broth ties the sauce together.

How To Make the Creamy Cajun Chicken Spaghetti

Step 1: Season and Cook the Chicken

Season the chicken breasts generously with Cajun seasoning, salt, black pepper, and paprika. In a large skillet, heat olive oil and sear the chicken on both sides until golden brown and cooked through. Remove and set aside.

Step 2: Boil the Pasta

Bring a pot of salted water to a boil and cook the spaghetti to al dente. Reserve some pasta water, then drain and set aside.

Step 3: Make the Garlic Mozzarella Sauce

In the same skillet, melt butter and sauté minced garlic until fragrant. Stir in heavy cream and chicken broth, simmering gently. Gradually whisk in mozzarella and parmesan until melted and smooth.

Step 4: Combine and Toss

Slice the cooked chicken and return it to the skillet. Add the drained spaghetti and toss to coat everything in the sauce. If needed, add a splash of pasta water for a silkier texture.

Step 5: Garnish and Serve

Sprinkle fresh parsley on top before serving. Serve hot and enjoy the creamy, spicy goodness.

Serving and Storing Creamy Cajun Chicken Spaghetti

This Creamy Cajun Chicken Spaghetti feeds about four people generously, making it ideal for family dinners or a cozy dinner party. Serve it hot right from the skillet with a sprinkle of fresh parsley and maybe an extra handful of parmesan on top. If you’re serving a crowd or making it ahead, keep it warm over low heat and add a splash of cream to loosen the sauce before serving.

Leftovers store well in an airtight container in the fridge for up to three days. To reheat, warm it slowly on the stove with a splash of cream or broth to bring the sauce back to its luscious texture. Avoid microwaving for too long, as it can separate the cream sauce.

What to Serve With Creamy Cajun Chicken Spaghetti?

Garlic Bread

Buttery and crisp garlic bread is perfect for mopping up the extra sauce.

Roasted Broccoli

Add a healthy touch with some oven-roasted broccoli tossed in olive oil and sea salt.

Caesar Salad

A crisp Caesar salad balances the richness of the pasta beautifully.

Grilled Asparagus

Slightly charred asparagus adds a fresh, green element to the meal.

Corn on the Cob

Grilled or boiled corn with a hint of butter and Cajun spices ties in the flavor theme perfectly.

Sauteed Spinach

Simple, garlicky spinach is a light, nutritious side that complements the dish.

Fried Green Tomatoes

For a Southern-inspired twist, add a side of crispy fried green tomatoes.

Red Wine or Sparkling Water

Serve with a glass of red wine for a bold pairing, or sparkling water with lemon for a fresh finish.

Want More Chicken Pasta Ideas?

If this Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce lit up your dinner table, you’ll want to try these flavorful favorites too:

• Creamy Chicken and Broccoli for a cozy weeknight classic.
• One Pot Creamy Cajun Sausage Pasta with smoky heat and easy cleanup.
• Lemon Garlic Butter Chicken Parmesan Linguine if you’re craving a zesty twist.
• Cheesy Baked Ziti for when you’re in the mood for ultimate baked comfort.
• Creamy Cajun Linguine if you love bold flavors with a creamy finish.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you add shrimp or a twist of lemon? Maybe you tossed in mushrooms?

I love hearing your creative takes on these dishes. Have questions? I’m happy to help make your version just right.

Explore beautifully curated health-boosting dinners and pasta inspiration on Zoe Recipes on Pinterest and discover your new go-to meals.

Conclusion

Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce delivers on both flavor and comfort. With tender chicken, a bold creamy sauce, and just the right touch of spice, it’s a pasta dish that never gets boring. This is one of those meals you’ll keep coming back to when you want dinner to feel special without the stress. Try it once, and you’ll understand why it’s a keeper.

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