Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce

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When bold Cajun spice meets creamy, cheesy indulgence, you get something truly irresistible. This Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce is the kind of dish that makes a weeknight feel like a weekend celebration. It brings together the rich flavors of Cajun-seasoned chicken and a velvety garlic mozzarella sauce that clings to every strand of fettuccine.

Perfect for cozy nights or impressing your dinner guests, this recipe doesn’t just deliver flavor—it offers comfort, warmth, and a kick of spice in every bite. Whether you’re a pasta lover or just need a quick but impressive dish to serve, this one ticks all the boxes for flavor, texture, and ease.

Why You’ll Love This Creamy Cajun Chicken Fettuccine

If you enjoy bold flavors and creamy textures, this pasta is a match made in heaven. The Cajun spices wake up your taste buds while the cheese sauce balances everything with its smooth, garlicky creaminess. It feels fancy without being fussy and works for both a family meal or a dinner for two. Plus, it’s a great way to switch up your pasta routine with something a little different, yet still deeply comforting.

What Kind of Fettuccine Should I Use?

Classic durum wheat fettuccine works perfectly for this recipe, offering the right bite and strength to hold up to the rich sauce. If you want to go a little more gourmet, fresh fettuccine from the refrigerated section adds an extra layer of decadence. And yes, you can use gluten-free fettuccine if needed—just cook it carefully to avoid mushiness. The sauce is the real star, so pick a pasta that lets it shine.

Ingredients for the Creamy Cajun Chicken Fettuccine

To get the full flavor experience, every ingredient plays its role in creating the perfect balance of spice, creaminess, and savory depth. Let’s walk through the essentials you’ll need to bring this recipe to life:

• Fettuccine pasta
• Chicken breasts
• Cajun seasoning
• Olive oil
• Butter
• Garlic
• Heavy cream
• Mozzarella cheese
• Parmesan cheese
• Salt and pepper
• Fresh parsley

The fettuccine pasta is the foundation of the dish, providing the perfect texture to carry the rich sauce. Chicken breasts, seasoned generously with Cajun seasoning, add protein and bold, smoky flavor. A mix of olive oil and butter helps brown the chicken and builds a flavorful base. Minced garlic brings its unmistakable aromatic punch, essential for a robust sauce.

The real magic happens when you pour in heavy cream, melt in mozzarella cheese, and stir in some Parmesan cheese for a hint of salty sharpness. Don’t forget a pinch of salt and pepper to taste and a sprinkle of fresh parsley for color and freshness right before serving.

How To Make the Creamy Cajun Chicken Fettuccine

Step 1: Season and Sear the Chicken

Start by slicing your chicken breasts into thin strips. Toss them with Cajun seasoning until well coated. In a large skillet, heat olive oil and butter over medium-high heat. Sear the chicken until golden on both sides and cooked through. Remove from the pan and set aside.

Step 2: Cook the Fettuccine

Boil a pot of salted water and cook the fettuccine according to package instructions. Drain and set aside, reserving a little pasta water.

Step 3: Make the Garlic Mozzarella Cheese Sauce

In the same skillet used for the chicken, add a bit more butter if needed and sauté the minced garlic until fragrant. Pour in the heavy cream and let it simmer gently. Add shredded mozzarella and Parmesan, stirring until melted and smooth. Season with salt and pepper to taste.

Step 4: Combine Everything

Add the cooked fettuccine to the skillet with the cheese sauce. Toss to coat well. If the sauce is too thick, add a splash of reserved pasta water to loosen it. Return the chicken to the pan and stir everything together.

Step 5: Garnish and Serve

Plate the pasta and top with freshly chopped parsley. Serve immediately while everything is creamy and hot.

How to Serve and Store Creamy Cajun Chicken Fettuccine

This creamy pasta dish is best served fresh and piping hot, right out of the skillet. The cheese sauce is at its silkiest when it first comes off the stove, so bring everyone to the table before you start plating. It makes enough to feed four hungry people comfortably, or six if you’re serving smaller portions alongside a salad or appetizer.

If you have leftovers, they keep well in the fridge for up to three days. Store them in an airtight container and reheat gently on the stove or in the microwave with a splash of cream or milk to revive the sauce. Avoid freezing, as creamy sauces tend to separate and lose their smooth texture after thawing.

What to Serve With Creamy Cajun Chicken Fettuccine?

Garlic Bread

A crispy, buttery slice of garlic bread is a perfect match for soaking up every drop of that cheesy sauce.

Caesar Salad

The tangy dressing and crunch from the croutons contrast beautifully with the rich pasta.

Roasted Asparagus

The charred, slightly bitter greens balance the creamy flavors in the dish.

Cajun Potato Soup

For a full-on comfort food experience, start your meal with a bowl of this flavorful soup.

Lemon Butter Salmon

If you’re going all out, a small portion of this fish adds a bright contrast to the richness of the fettuccine.

Steamed Broccoli

A healthy, light side that helps round out the meal without overpowering the main course.

Iced Tea or Sparkling Water

A refreshing drink is a must to balance the spice and creaminess of the dish.

Cheesecake or Fruit Tart

For dessert, opt for something sweet and slightly tangy to end the meal on a fresh note.

Want More Cajun-Inspired Ideas?

If you’re loving the bold flavors in this Creamy Cajun Chicken Fettuccine, you’ll want to keep the spice alive with these other crave-worthy dishes from the site:

• Try our One Pot Creamy Cajun Sausage Pasta for another simple weeknight favorite with smoky sausage.
• Warm up with a bowl of Cajun Potato Soup that hits all the cozy notes.
• Our Creamy Cajun Linguine is another pasta variation worth savoring.
• For a lighter bite, Zesty Lime Shrimp and Avocado Salad brings that same flavorful punch with a refreshing twist.
• And if you’re hosting a crowd, Cheeseburger Sliders with Hawaiian Rolls add that Cajun spice with a playful flair.

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Let me know how yours turned out! Did you use chicken thighs instead? Add extra garlic? I’m always curious how others make this dish their own. Share your thoughts, tips, or questions below and let’s chat!

Explore beautifully curated health-boosting drinks and more dinner recipes on Zoe Recipes on Pinterest and discover your new go-to for weeknight inspiration.

Conclusion

Creamy Cajun Chicken Fettuccine with Garlic Mozzarella Cheese Sauce is a flavor-packed recipe that combines spice, richness, and a hint of freshness in every forkful. It’s easy enough to whip up on a busy evening, but delicious enough to serve when you want to impress. Whether it’s your first time making it or your new weekly go-to, this dish will never let you down.

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