Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

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This Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce is one of those dishes that completely redefines weeknight dinners. Bold, spicy, and indulgently creamy, it brings together the soul-warming flavors of Cajun spice with the familiar comfort of cheesy spaghetti. Imagine tender ground beef simmered in a velvety sauce made from three luscious cheeses, all hugging perfectly cooked spaghetti strands. It’s the kind of meal that leaves everyone at the table asking for seconds.

What makes this spaghetti truly special is the balance. The Cajun seasoning provides that perfect heat without overpowering, while the cheeses add depth, creaminess, and a little tang. And with every twirl of your fork, you get a generous bite of creamy, beefy, spicy goodness. Whether you’re cooking for your family or having a casual dinner with friends, this recipe is guaranteed to be a crowd-pleaser.

Why You’ll Love This Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

From the first bite, this spaghetti delivers layers of flavor that feel like a warm hug. The Cajun spices awaken your palate, while the trio of cheeses melts into a silky sauce that coats every strand. It’s a restaurant-worthy dish that you can whip up at home in under an hour, making it ideal for busy nights when you still want something that feels like a treat. Plus, it’s hearty and satisfying without being overly heavy, so you get comfort food bliss without the post-dinner slump.

What Kind of Parmesan Should I Use?

For the best flavor and melt, you’ll want to use freshly grated Parmesan cheese rather than the shelf-stable pre-grated kind. The freshly grated version melts more smoothly and adds a rich, nutty finish to the sauce that ties everything together. If you can, pair it with a good quality mozzarella and a creamy white cheddar to complete the trio of cheeses that make this sauce unforgettable.

Ingredients for the Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

What makes this dish so rich and flavorful is the carefully chosen blend of ingredients that each bring their own delicious purpose. The Cajun spices wake up the taste buds, the trio of cheeses adds indulgent creaminess, and the ground beef makes it satisfyingly hearty.

• Spaghetti
• Ground beef
• Cajun seasoning
• Garlic cloves
• Heavy cream
• Cream cheese
• Mozzarella cheese
• White cheddar cheese
• Parmesan cheese
• Butter
• Salt and pepper
• Olive oil
• Fresh parsley

How To Make the Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil and cook the spaghetti until al dente according to the package directions. Reserve a cup of pasta water, then drain and set aside.

Step 2: Brown the Beef

In a large skillet, heat olive oil over medium-high heat. Add the ground beef and cook until browned, breaking it up as it cooks. Season with Cajun seasoning, salt, and pepper. Once fully cooked, transfer the beef to a bowl and set aside.

Step 3: Start the Sauce

In the same skillet, melt butter and sauté the garlic until fragrant. Pour in the heavy cream and stir in the cream cheese until melted and smooth. Gradually add the mozzarella, white cheddar, and Parmesan, stirring until the sauce is rich and creamy.

Step 4: Combine and Simmer

Return the cooked beef to the skillet with the cheese sauce and stir to combine. Add the cooked spaghetti and toss until fully coated. Use reserved pasta water, a splash at a time, to thin the sauce to your liking.

Step 5: Garnish and Serve

Sprinkle chopped fresh parsley on top and serve immediately while everything is hot and creamy. Enjoy every flavorful, cheesy, spicy bite!

How to Serve and Store This Creamy Cajun Beef Spaghetti

This creamy, cheesy Cajun beef spaghetti is best served immediately, piping hot from the skillet when the cheese sauce is at its silkiest. It feeds about 4 to 6 people generously, making it perfect for a family dinner or small gathering. Serve it directly from the pan for a cozy, rustic feel, or plate it neatly with a sprinkle of extra Parmesan and parsley on top.

If you find yourself with leftovers, don’t worry—this dish stores beautifully. Let it cool completely, then transfer it to an airtight container and refrigerate for up to 3 days. To reheat, add a splash of milk or cream in a skillet over low heat and stir until warmed through and creamy again. Avoid microwaving it for too long as it can separate the sauce.

What to Serve With Creamy Cajun Beef Spaghetti?

Garlic Bread

Crispy on the outside and buttery in the middle, garlic bread is a must-have side. It’s great for scooping up every last bit of that dreamy cheese sauce.

Simple Arugula Salad

A peppery arugula salad with lemon vinaigrette adds a fresh contrast to the richness of the pasta and helps cleanse the palate.

Roasted Vegetables

Roasted Brussels sprouts or zucchini add color and texture, and they bring a slightly charred flavor that pairs well with the Cajun spices.

Grilled Corn on the Cob

The sweetness of grilled corn balances the heat from the Cajun seasoning and brings a bit of summer to your plate.

Parmesan Roasted Potatoes

Yes, double carbs—because when they’re this good, why not? These crispy potatoes are a fantastic complement to the creamy pasta.

Sautéed Spinach with Garlic

This quick veggie side adds nutrients and a little earthiness that cuts through the richness.

Southern Coleslaw

Creamy coleslaw with a tangy kick offers a cool, crunchy contrast that makes each bite of pasta pop.

Sparkling Water or Sweet Tea

For drinks, a tall glass of sweet tea or flavored sparkling water refreshes the palate between spicy, cheesy bites.

Want More Pasta Ideas with a Cajun Twist?

If you love the flavors in this creamy Cajun spaghetti, you’re going to fall for these other pasta and spice-loaded favorites from the blog:

• One Pot Creamy Cajun Sausage Pasta is a quick and hearty favorite when you want full flavor with minimal dishes.
• Creamy Cajun Linguine brings a luxurious sauce that’s rich, bold, and made to impress.
• Cheesy Baked Ziti gives you that oven-baked comfort with a golden cheesy crust.
• Creamy Chicken and Broccoli for a milder, kid-friendly creamy pasta night.
• Cheesesteak Tortellini in Rich Provolone Sauce is your go-to for cheesy decadence in every bite.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you use a spicier Cajun mix? Did you swap in chicken or sausage instead of beef?

I love hearing how others make these recipes their own. Questions are welcome too—let’s help each other cook better.

Explore beautifully curated pasta recipes and bold dinner ideas on Zoe Recipes on Pinterest and discover your new go-to for comfort with a kick: Zoe Recipes on Pinterest.

Conclusion

Creamy Cajun Beef Spaghetti with Three-Cheese Parmesan Sauce is more than just a meal; it’s a celebration of bold flavors and cozy comfort. It’s perfect for when you need something a little indulgent but still want it ready in under an hour. This is the kind of dish that turns a simple evening into a memorable one—creamy, spicy, cheesy, and absolutely unforgettable.

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