Cajun Garlic Butter Chicken Penne in Creamy Parmesan Sauce

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Rich, spicy, and irresistibly creamy, this Cajun Garlic Butter Chicken Penne in Creamy Parmesan Sauce is a dish that transforms any ordinary dinner into something unforgettable. It brings together tender seasoned chicken, penne pasta cooked to perfection, and a creamy Parmesan sauce that ties it all together with garlicky, buttery decadence.

This recipe is comfort food with a Cajun twist. The bold Cajun spices play beautifully against the creamy Parmesan sauce, making every bite full of flavor and warmth. Whether you’re cooking for your family or hosting guests, this dish feels both indulgent and approachable.

Why You’ll Love This Cajun Garlic Butter Chicken Penne

You’ll love how this meal hits all the right notes. It has the spice you crave from Cajun seasoning, the silky texture of a well-balanced cream sauce, and juicy, golden chicken breast slices. The butter and garlic deepen the flavor, turning the whole dish into a luscious, crave-worthy experience. Plus, it’s a one-pan wonder that comes together quickly, making cleanup a breeze.

What Kind of Chicken Should I Use?

For this recipe, boneless, skinless chicken breasts are ideal because they cook quickly and absorb the Cajun seasoning beautifully. However, if you prefer darker meat, boneless chicken thighs are also a flavorful and juicy option that works perfectly with the garlic butter base and creamy sauce.

Ingredients for the Cajun Garlic Butter Chicken Penne in Creamy Parmesan Sauce

This dish is built on layers of flavor, and the ingredients come together to create a rich, spicy, and satisfying pasta dish. From the seasoning to the sauce, every component plays an important role in achieving the perfect creamy Cajun balance.

• Chicken breasts
• Penne pasta
• Butter
• Garlic cloves
• Cajun seasoning
• Heavy cream
• Grated Parmesan cheese
• Salt and black pepper
• Olive oil
• Parsley

How To Make the Cajun Garlic Butter Chicken Penne in Creamy Parmesan Sauce

Step 1: Season and Sear the Chicken

Season both sides of your chicken breasts with Cajun seasoning, salt, and pepper. In a hot skillet with olive oil, sear the chicken until golden and cooked through. Set aside to rest.

Step 2: Cook the Pasta

Boil a pot of salted water and cook the penne until al dente. Drain and set aside, reserving some of the pasta water.

Step 3: Make the Garlic Butter Base

In the same skillet, melt butter and sauté minced garlic until fragrant. This creates the foundation of the sauce.

Step 4: Build the Creamy Parmesan Sauce

Add heavy cream to the garlic butter and stir in the grated Parmesan cheese. Simmer gently, letting the cheese melt into a smooth, velvety sauce.

Step 5: Bring Everything Together

Slice the cooked chicken and return it to the skillet. Add the cooked pasta and a splash of reserved pasta water if needed. Toss everything to coat in the sauce.

Step 6: Finish and Garnish

Adjust seasoning, then sprinkle fresh parsley over the top before serving. Serve warm and enjoy the spicy, creamy comfort of every bite.

How to Serve and Store Cajun Garlic Butter Chicken Penne in Creamy Parmesan Sauce

This creamy Cajun chicken pasta is best served hot straight from the pan. The sauce hugs each bite of pasta and chicken, making it comforting and indulgent. It feeds 4 to 6 people depending on portion sizes, and pairs beautifully with a crisp side salad or warm garlic bread.

To store leftovers, allow the pasta to cool before transferring to an airtight container. It can be refrigerated for up to 3 days. When reheating, add a splash of cream or milk to loosen the sauce and warm gently on the stovetop or in the microwave.

What to Serve With Cajun Garlic Butter Chicken Penne?

Classic Caesar Salad

A crisp Caesar salad balances the richness of the pasta and brings refreshing crunch to the plate.

Roasted Vegetables

Caramelized roasted broccoli, bell peppers, or asparagus add a healthy and flavorful contrast.

Garlic Bread

Buttery and golden, garlic bread is perfect for soaking up any extra creamy Parmesan sauce.

Parmesan Roasted Potatoes

If you’re serving a bigger crowd, crispy roasted potatoes with Parmesan tie in deliciously with the main dish.

Sauteed Green Beans

Simply seasoned green beans offer a light side to balance the boldness of the Cajun flavors.

Tomato Basil Bruschetta

This adds a zesty, fresh flavor and makes a great starter to your meal.

Lemon Herb Couscous

A tangy, herb-filled couscous dish brings brightness and a soft texture to the table.

Sweet Corn on the Cob

Grilled or boiled corn is naturally sweet and complements the spicy pasta perfectly.

Want More Pasta Dinner Ideas?

If you loved this Cajun Garlic Butter Chicken Penne in Creamy Parmesan Sauce, here are some other bold and satisfying dishes to try:

• Creamy Cajun Linguine for another spicy twist on creamy pasta.
• Cheesy Beef Enchilada Tortellini blends Tex-Mex flavors into a cozy pasta meal.
• Lemon Garlic Butter Chicken Parmesan Linguine for a lighter citrusy take on chicken pasta.
• Creamy Chicken and Broccoli gives you a comforting, veggie-packed option.
• One Pot Creamy Cajun Sausage Pasta is a great next choice if you’re craving more heat and simplicity.

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And let me know in the comments how yours turned out. Did you try a different pasta shape? Add extra veggies or spice it up even more?

I love seeing your takes on my recipes and how you make them your own. If you have any questions, feel free to ask!

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Conclusion

Cajun Garlic Butter Chicken Penne in Creamy Parmesan Sauce is one of those recipes that feels indulgent without being overly complicated. The bold flavors and creamy texture make it a true crowd-pleaser, and once you make it, it’s sure to become a regular in your meal rotation.

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