Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

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When comfort food meets a little spice, magic happens in the form of this Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo. This dish combines tender chicken pieces tossed in bold Cajun seasoning, perfectly twirled pasta, and a dreamy mozzarella Alfredo sauce that clings to every twist and turn. It’s creamy, it’s cheesy, and it delivers just the right amount of heat to keep things exciting.

The beauty of this pasta lies in its balance. The Cajun spices bring warmth and a slightly smoky flavor, while the mozzarella Alfredo sauce cools everything down with its creamy, melty goodness. It’s a dish that feels indulgent yet comes together easily for a weeknight dinner that’s sure to impress.

Why You’ll Love This Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

You’ll fall in love with the layers of flavor in this recipe. The spiced chicken packs a punch, but the creamy Alfredo brings a soothing counterbalance. The mozzarella adds a stretchy, satisfying texture that makes each bite more enjoyable than the last. It’s also a versatile dish — you can serve it family-style, dress it up for a dinner party, or save leftovers for a next-day meal that tastes just as good.

What Kind of Pasta Should I Use?

For this recipe, twisted pasta like rotini or fusilli works best. Their spiral shape holds onto the sauce beautifully, ensuring every bite is loaded with flavor. However, you can easily swap in other types like penne or cavatappi if that’s what you have on hand. The key is choosing a pasta shape with grooves or texture so the Alfredo clings on just right.

Ingredients for the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

This dish brings together simple ingredients to create bold flavor. Each element plays a vital role, especially when it comes to layering spices with creamy textures. You don’t need anything fancy — just quality ingredients that combine into something spectacular.

• Twisted pasta (rotini or fusilli)
• Chicken breasts
• Cajun seasoning
• Olive oil
• Butter
• Garlic cloves
• Heavy cream
• Mozzarella cheese
• Parmesan cheese
• Salt
• Black pepper
• Parsley

The pasta is your flavor base, the chicken brings heartiness and spice, and the combination of cheeses and cream transforms the dish into a creamy dream.

How To Make the Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

Step 1: Cook the Pasta

Boil the pasta in salted water according to the package instructions. Drain and set aside, reserving some pasta water.

Step 2: Season and Cook the Chicken

Slice the chicken breasts into thin strips. Rub them well with Cajun seasoning. Heat olive oil in a skillet and cook the chicken until golden and fully cooked. Remove and set aside.

Step 3: Make the Mozzarella Alfredo Sauce

In the same skillet, melt butter and sauté minced garlic until fragrant. Pour in the heavy cream, letting it simmer gently. Stir in mozzarella and Parmesan until melted and smooth. Season with salt and black pepper.

Step 4: Combine Everything

Return the cooked pasta and chicken to the skillet. Toss everything together, adding a splash of pasta water if needed to loosen the sauce.

Step 5: Garnish and Serve

Top with chopped parsley and extra cheese if desired. Serve hot and enjoy immediately.

Serving and Storing Your Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo

This pasta is best served straight from the skillet while it’s still warm and creamy. The sauce clings best when hot, delivering the perfect balance of spice and richness in every bite. It feeds about 4 to 5 people generously, making it great for a family meal or small dinner gathering.

If you have leftovers, store them in an airtight container in the refrigerator for up to three days. Reheat gently on the stove with a splash of milk or cream to revive the silky texture. Microwaving works too, though stirring halfway through helps maintain the creamy consistency.

What to Serve With Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo?

Garlic Bread

The perfect sidekick for soaking up every last bit of that Alfredo sauce. Crisp edges and buttery flavor match beautifully.

Simple Green Salad

A fresh salad with a tangy vinaigrette cuts through the richness and adds a refreshing contrast.

Roasted Broccoli

Lightly charred and seasoned broccoli florets pair nicely with the creamy pasta and bring some crunch.

Corn on the Cob

Boiled or grilled, sweet corn works as a light, juicy side that complements the heat of the Cajun spice.

Caprese Skewers

Tomato, basil, and mozzarella bites add a cool and colorful touch that harmonizes with the Alfredo base.

Sauteed Spinach

Quickly cooked with garlic, spinach adds a nutritious green element to round out the plate.

Fresh Fruit Salad

A chilled medley of melon, grapes, and berries is a clean and sweet way to finish the meal.

Want More Chicken Pasta Ideas?

If you love this Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo, you’ll probably enjoy these other comfort food favorites from the blog:

• Try this hearty and spicy One Pot Creamy Cajun Sausage Pasta for a smoky twist.
• For a zesty touch, the Lemon Garlic Butter Chicken Parmesan Linguine brings brightness to every bite.
• If creamy is your style, don’t miss the Creamy Chicken and Broccoli for an easy and wholesome option.
• The Easy One Pan Mozzarella Chicken is great when you’re short on time but want big flavor.

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Let me know in the comments how your version turned out. Did you go spicier or add veggies? Maybe even swap in shrimp instead of chicken?

I always enjoy hearing your kitchen stories and tweaks. Sharing is how we learn and grow together as home cooks.

Explore beautifully curated health-boosting drinks and delicious dinners on Zoe Recipes on Pinterest and discover your next favorite meal inspiration!

Conclusion

Creamy Cajun Chicken Twisted Pasta with Mozzarella Alfredo brings together everything we crave in one dish: bold spice, velvety sauce, cheesy richness, and satisfying pasta. It’s the kind of meal that fills the room with good aromas and warms the soul. Whether it’s a weekday treat or a special dinner with loved ones, it delivers every time.

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