Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

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There’s something undeniably comforting about a big bowl of creamy pasta, and when you add a touch of Cajun spice and juicy chicken into the mix, it turns into a crave-worthy meal that feels both indulgent and cozy. Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce is just that kind of dish. It’s the kind of weeknight dinner you make once and immediately add to your rotation.

This recipe brings together bold Cajun flavors with a silky mozzarella Alfredo sauce that clings to every twist of rotini. The chicken is seared to golden perfection, seasoned with just the right amount of kick, and then enveloped in a sauce that feels luxurious without being fussy. It balances richness with spice, and texture with creaminess, making each bite incredibly satisfying.

Why You’ll Love This Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

This pasta is packed with flavor and feels like a restaurant-quality meal you can whip up in under 45 minutes. It’s hearty and filling, perfect for cooler evenings or when you need comfort in a bowl. The rotini pasta holds the sauce beautifully, the Cajun spices add warmth without overwhelming heat, and the mozzarella Alfredo sauce makes everything irresistibly creamy.

Plus, it’s a flexible recipe. Want to add bell peppers, spinach, or mushrooms? Go for it. Prefer shrimp over chicken? That works too. It’s the perfect blank canvas for creativity, while still delivering that core Cajun-creamy satisfaction.

What Kind of Pasta Should I Use?

Rotini is ideal for this dish because its spiral shape grabs onto the sauce, ensuring every bite is full of flavor. However, you can easily swap in penne, fusilli, or even fettuccine if that’s what you have on hand. The goal is to choose a pasta that will embrace that luscious mozzarella Alfredo and hold onto the Cajun-spiced chicken chunks like they were meant to be together.

Ingredients for the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

For a pasta dish this flavorful, the ingredients are surprisingly simple. Each one brings something special to the table, helping to build layers of flavor and richness. Freshness is key, especially for the chicken and garlic, to make sure your sauce sings with depth and the spice lingers beautifully.

• Rotini Pasta
• Boneless Skinless Chicken Breast
• Olive Oil
• Cajun Seasoning
• Salt
• Black Pepper
• Garlic Cloves
• Butter
• Heavy Cream
• Mozzarella Cheese
• Parmesan Cheese
• Fresh Parsley (optional)

Each of these ingredients helps balance out the richness and spice. The rotini provides texture and structure, while the mozzarella and cream create that ultra-smooth Alfredo base. Cajun seasoning brings a bold punch, and garlic adds that perfect aromatic note.

How To Make the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Step 1: Cook the Rotini

Bring a large pot of salted water to a boil and cook the rotini pasta until al dente according to package instructions. Drain and set aside.

Step 2: Season and Cook the Chicken

Cut chicken breasts into bite-sized pieces. Season with Cajun seasoning, salt, and pepper. Heat olive oil in a skillet over medium-high heat and sear the chicken until fully cooked and golden brown. Transfer to a plate and keep warm.

Step 3: Make the Alfredo Base

In the same skillet, reduce heat to medium and add butter. Once melted, add minced garlic and cook until fragrant, about 1 minute. Pour in the heavy cream, stirring to deglaze the pan. Let it simmer gently for 3-4 minutes.

Step 4: Add the Cheese

Lower the heat and stir in shredded mozzarella and parmesan cheese. Whisk until melted and the sauce is smooth and creamy.

Step 5: Combine Everything

Add the cooked rotini and seared chicken into the skillet. Toss everything together until well coated with the sauce. Let it heat through for another minute or two.

Step 6: Garnish and Serve

Top with chopped fresh parsley for a touch of color and brightness. Serve hot and enjoy that perfect bite of spicy, creamy pasta heaven.

Serving and Storing This Creamy Cajun Chicken Rotini

This recipe feeds about 4 people generously, making it perfect for family dinners or a cozy gathering with friends. Serve it straight from the skillet for that rustic feel, or plate it with a sprinkle of extra parmesan and a twist of black pepper for something a little more refined.

If you have leftovers, store them in an airtight container in the refrigerator for up to 3 days. When reheating, add a splash of cream or milk to help loosen the sauce, as it can thicken in the fridge. A quick warm-up on the stove or in the microwave brings it right back to its original creamy glory.

What to Serve With Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce?

Garlic Bread with Herb Butter

Crunchy on the outside and fluffy on the inside, garlic bread with a herby butter spread pairs beautifully with the creamy, spicy pasta.

Roasted Broccoli or Asparagus

Oven-roasted green veggies balance out the richness of the Alfredo sauce and add a touch of freshness.

Caesar Salad

Crisp romaine lettuce tossed with creamy dressing, croutons, and a dusting of parmesan makes a refreshing contrast.

Grilled Corn on the Cob

Sweet and smoky corn rounds out the heat of the Cajun seasoning and brings a summery twist.

Lemon Parmesan Zucchini

Lightly sautéed zucchini slices with lemon juice and parmesan offer brightness and a tender bite.

Caprese Salad

Fresh mozzarella, tomatoes, and basil with balsamic glaze make a vibrant and juicy side to complement the creamy pasta.

Crispy Brussels Sprouts

Pan-seared or air-fried Brussels sprouts with a touch of balsamic drizzle are crispy, caramelized, and crave-worthy.

Baked Sweet Potato Wedges

For something heartier, go with baked sweet potato wedges. Their natural sweetness cuts through the savory richness of the Alfredo sauce.

Want More Pasta Dinner Ideas?

If you love this creamy Cajun chicken rotini, there are plenty more comforting pasta recipes to explore:

• Try the Cheesy Beef Enchilada Tortellini for a zesty twist on Tex-Mex.
• Dig into Creamy Cajun Linguine for more of that bold, spicy flavor.
• Warm up with a bowl of Cajun Potato Soup, a hearty companion to any pasta night.
• For a comforting baked dish, try the Loaded Cheddar Ranch Beef and Sweet Corn Rotini Bake.
• Or keep it classic with Creamy Chicken and Broccoli that never disappoints.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you spice it up more or go heavy on the cheese? Did you try adding shrimp or mushrooms?

I love hearing how others make these recipes their own. Questions are welcome too – let’s help each other cook smarter.

Explore beautifully curated health-boosting dinners and comforting favorites on Zoe Recipes on Pinterest and find your next weeknight win.

Conclusion

Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce is everything you want in a comfort food dinner. It’s bold, creamy, and comes together easily enough to make even on busy weeknights. With just the right balance of heat and richness, it’s the kind of recipe that satisfies cravings and earns you repeat requests from the whole table.

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