Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce

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When comfort food meets a little bit of Cajun flair, magic happens in the kitchen. Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce is a warm, savory, and slightly spicy dish that wraps around your taste buds with every creamy bite. This isn’t just another pasta dinner—it’s a rich, soul-satisfying experience layered with bold flavors and cheesy goodness.

Perfect for busy weeknights yet indulgent enough for special occasions, this recipe combines tender chicken with the richness of garlic and mozzarella in a silky sauce that clings beautifully to spiraled rotini pasta. It’s the kind of meal that brings everyone to the table with anticipation and leaves nothing but empty plates.

Why You’ll Love This Creamy Cajun Chicken Rotini

This dish brings together the bold spices of Cajun cuisine with a creamy, cheesy sauce that balances heat with richness. The rotini holds onto every bit of flavor, ensuring each forkful is coated in goodness. It’s quick to make, incredibly comforting, and offers enough flavor to keep it exciting meal after meal.

Whether you’re cooking for family or entertaining guests, this recipe impresses without requiring hours in the kitchen. Plus, it’s highly customizable—turn up the heat, swap in your favorite veggies, or double the batch for leftovers that reheat like a dream.

What Kind of Rotini Should I Use?

Short pasta is ideal for saucy dishes, and rotini is a standout for its ability to hold onto sauces thanks to its spiral shape. While traditional wheat rotini works beautifully, you can opt for whole wheat, gluten-free, or even chickpea-based rotini for different textures and nutritional benefits. Choose one that cooks al dente and pairs well with creamy sauces to soak up all that garlic mozzarella magic.

Ingredients for the Creamy Cajun Chicken Rotini

To make this Creamy Cajun Chicken Rotini unforgettable, each ingredient plays a role in building layers of flavor and texture. From bold seasoning to melty cheese, these are the components that make the dish sing.

• Chicken breast — Lean and juicy, it soaks up the Cajun seasoning and brings hearty protein to the meal.
• Rotini pasta — The spiral shape is perfect for clinging onto the creamy garlic mozzarella sauce.
• Cajun seasoning — Adds that essential smoky heat that defines the dish’s flavor profile.
• Garlic — Infuses the sauce with rich, aromatic depth.
• Butter — Gives the base of the sauce a luxurious, velvety texture.
• All-purpose flour — Helps thicken the sauce just enough to coat every piece of pasta.
• Milk — Forms the creamy foundation of the sauce.
• Mozzarella cheese — Melts into the sauce to create that signature cheesy pull and mild richness.
• Salt and pepper — Essential for balancing all the other bold flavors.
• Parsley — A fresh garnish to brighten and finish the dish.

How To Make the Creamy Cajun Chicken Rotini

Step 1: Season and Sear the Chicken

Begin by cutting the chicken breast into bite-sized pieces. Season generously with Cajun seasoning, salt, and pepper. Heat a pan with a bit of oil and sear the chicken until golden and cooked through. Remove and set aside.

Step 2: Cook the Pasta

While the chicken cooks, boil a pot of salted water and cook the rotini pasta until al dente. Drain and set aside, reserving some pasta water.

Step 3: Build the Garlic Mozzarella Sauce

In the same pan, melt butter and add minced garlic, cooking until fragrant. Stir in the flour to create a roux. Slowly whisk in the milk, letting the sauce thicken. Then, stir in mozzarella cheese until fully melted and smooth.

Step 4: Combine and Finish

Add the cooked chicken and pasta into the sauce. Mix everything gently to coat. If the sauce is too thick, splash in reserved pasta water. Sprinkle with fresh parsley before serving.

Serving and Storing Creamy Cajun Chicken Rotini

This Creamy Cajun Chicken Rotini serves about 4 to 5 people generously, making it ideal for a family dinner or a small gathering with friends. The rich sauce and hearty chicken make it a satisfying meal on its own, but it pairs wonderfully with sides if you want to stretch it further.

For storing, let any leftovers cool completely before transferring to an airtight container. They keep well in the refrigerator for up to 4 days. When reheating, you may want to add a splash of milk or water to loosen the sauce and revive its creamy texture. This dish doesn’t freeze as well due to the dairy content, so enjoy it fresh if you can.

What to Serve With Creamy Cajun Chicken Rotini?

Garlic Bread

A crusty, buttery slice of garlic bread makes the perfect companion, ideal for soaking up any leftover sauce on the plate.

Roasted Broccoli

The crisp-tender texture and slight char of roasted broccoli offer a refreshing contrast to the creamy richness of the pasta.

Caesar Salad

The crunch of romaine and tang of Caesar dressing cuts through the creaminess for a balanced meal.

Sauteed Green Beans

Simple, quick, and lightly seasoned, they add a welcome touch of green and freshness.

Cornbread Muffins

For a Southern twist, serve this dish alongside sweet cornbread muffins that complement the Cajun spices.

Grilled Zucchini

Light and slightly smoky, grilled zucchini rounds out the meal with a summery flair.

Tomato Cucumber Salad

Cool and crisp, this salad offers a bright bite that cleanses the palate between creamy forkfuls.

Sparkling Lemon Water

Sometimes, all you need is a fizzy citrus drink to refresh and balance the spice and richness of the dish.

Want More Pasta Dinner Ideas?

If you love this Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce, you’re going to want to check out these other mouthwatering pasta dinners from my kitchen:

• One-Pot Creamy Cajun Sausage Pasta for a smoky, hearty twist with minimal cleanup.
• Creamy Cajun Linguine if you crave long noodles with bold flavor.
• Creamy Jamaican Shrimp Rasta Pasta for an island-inspired spicy treat.
• Cheesy Beef Enchilada Tortellini when you want to blend Tex-Mex with cheesy pasta.
• Creamy Chicken and Broccoli for a veggie-packed comfort dish.

Save This Recipe For Later

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And let me know in the comments how yours turned out. Did you add mushrooms or extra spice? Maybe you swapped in a different pasta?

I love hearing how you make these recipes your own. Questions are welcome too—let’s help each other cook smarter.

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Conclusion

Creamy Cajun Chicken Rotini with Garlic Mozzarella Sauce is the kind of dish that turns ordinary nights into something memorable. It blends the bold kick of Cajun seasoning with the comfort of cheesy, garlicky pasta in a way that’s both easy and irresistible. Keep it in your meal rotation for when you want flavor-packed satisfaction with little effort. Once you taste it, you’ll be making it again and again.

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