Creamy Cajun Chicken Bowtie Pasta with Garlic Cheese Sauce

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If you’re craving comfort food with a spicy, cheesy kick, this Creamy Cajun Chicken Bowtie Pasta with Garlic Cheese Sauce is about to become your new weeknight favorite. Juicy, pan-seared chicken breast tossed in a rich, velvety garlic cheese sauce, wrapped around tender bowtie pasta with that unmistakable Cajun flair – it’s every bite you dream of when you want bold flavors and cozy satisfaction.

This dish is perfect for anyone who loves restaurant-style pasta but wants the ease of making it at home. The creamy sauce gets an irresistible depth from garlic and cheddar, while the Cajun seasoning gives everything a smoky, spicy edge. Whether you’re cooking for the family or prepping leftovers for the week, this pasta checks every box.

Why You’ll Love This Creamy Cajun Chicken Bowtie Pasta

This pasta isn’t just another cheesy chicken dish. It’s got layers. The Cajun seasoning brings heat and smokiness, the garlic cheese sauce is silky and rich, and the bowtie pasta captures all that flavor in its little folds. Plus, it comes together in under 40 minutes, making it perfect for busy weeknights. You get the feel of a gourmet meal with minimal fuss and ingredients you probably already have in your kitchen.

And the best part? It’s flexible. You can swap the protein, add veggies, or tone down the spice to suit your mood.

What Kind of Pasta Should I Use?

Bowtie pasta, or farfalle, is ideal here because it holds the creamy sauce in every crevice and adds texture to every bite. That said, you can use penne, rigatoni, or even rotini if that’s what you have on hand. The key is a pasta shape that grips the sauce well and doesn’t turn mushy with the creamy base.

Ingredients for the Creamy Cajun Chicken Bowtie Pasta with Garlic Cheese Sauce

To make this dish sing, you’ll need ingredients that layer spice, creaminess, and a hint of sharpness. Each component plays a part in creating that perfect Cajun bite.

• Chicken breast: Boneless and skinless, sliced thinly for quick cooking and maximum seasoning coverage.
• Bowtie pasta: Its shape helps scoop up the garlic cheese sauce in every bite.
• Cajun seasoning: This is the flavor powerhouse of the dish, giving it that smoky heat.
• Garlic: Freshly minced for that aromatic base that deepens the flavor of the cheese sauce.
• Heavy cream: Essential for a thick, luscious sauce that clings to the pasta.
• Cheddar cheese: Sharp cheddar gives a bold, cheesy body to the sauce.
• Parmesan cheese: Adds a salty, nutty finish that balances the creamy richness.
• Butter: For sautéing the garlic and adding a silky texture to the sauce.
• Olive oil: Helps sear the chicken and adds depth to the overall dish.
• Salt and pepper: Essential for seasoning each component to perfection.

How To Make the Creamy Cajun Chicken Bowtie Pasta with Garlic Cheese Sauce

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil and cook the bowtie pasta until al dente. Drain and set aside, reserving about 1/2 cup of the pasta water.

Step 2: Season and Cook the Chicken

Season the thin-sliced chicken breasts with Cajun seasoning, salt, and pepper. In a large skillet over medium-high heat, add olive oil and sear the chicken until golden brown and fully cooked. Remove and set aside.

Step 3: Make the Garlic Cheese Sauce

In the same skillet, reduce heat to medium and melt butter. Add the minced garlic and sauté until fragrant. Pour in the heavy cream, then slowly stir in the cheddar and Parmesan cheeses. Whisk until the sauce is smooth and creamy.

Step 4: Combine Everything

Add the cooked pasta and chicken back into the skillet with the sauce. Toss everything together until well coated. If the sauce feels too thick, add a splash of the reserved pasta water until you reach your desired consistency.

Step 5: Taste and Serve

Taste for seasoning and adjust with additional Cajun seasoning or salt if needed. Serve hot and garnish with a sprinkle of Parmesan or chopped parsley if you like a fresh finish.

How to Serve and Store This Creamy Cajun Chicken Bowtie Pasta

This creamy Cajun pasta is best served immediately while the sauce is hot and velvety. It makes a generous dinner for four and is equally delicious the next day. If you’re planning leftovers, store the pasta in an airtight container in the refrigerator for up to 3 days.

When reheating, you may need to add a splash of milk or cream to loosen the sauce and bring back that creamy texture. Gently reheat on the stovetop or in the microwave, stirring occasionally to distribute the heat evenly.

What to Serve With Creamy Cajun Chicken Bowtie Pasta?

Garlic Bread

The garlicky, buttery crunch of warm garlic bread is a perfect match for this creamy dish.

Caesar Salad

A chilled Caesar salad with crisp romaine, Parmesan, and crunchy croutons adds freshness and contrast.

Roasted Broccoli

The earthy, slightly charred taste of roasted broccoli cuts through the richness of the pasta.

Corn on the Cob

Sweet corn pairs beautifully with Cajun spice, offering a juicy balance.

Fried Green Tomatoes

These crispy bites offer a tangy contrast and Southern charm to the dish.

Coleslaw

A creamy or vinegar-based slaw brings a crunchy, tangy element that balances the creaminess.

Sautéed Spinach

Lightly wilted spinach with a touch of garlic is a simple, healthy side that complements the bold flavors.

Grilled Zucchini

A fresh, smoky bite from grilled zucchini rounds out the plate and keeps it vibrant.

Want More Pasta Ideas with a Bold Twist?

If you love the bold, creamy spice of this Cajun Chicken Bowtie Pasta, you’re going to want to explore more flavorful pasta creations. Check out these comforting dishes that deliver on taste:

• One-Pot Creamy Cajun Sausage Pasta for a smoky, sausage-packed alternative.
• Cheesy Baked Ziti when you’re in the mood for oven-baked comfort.
• Creamy Cajun Linguine if you’re craving something similar with a different pasta spin.
• Creamy Garlic Parmesan Tortellini with Sausage and Broccoli for extra cheesy goodness with a veggie twist.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it anytime.

And let me know in the comments how yours turned out! Did you go heavy on the Cajun or add your own twist? Maybe a veggie or two snuck in?

I love seeing how you make these dishes your own. Feel free to drop questions, too—we’re all here to share and cook better together.

Explore even more flavor-packed, health-boosting meals and comfort food creations over on Zoe Recipes on Pinterest. You might just find your next weeknight go-to!

Conclusion

This Creamy Cajun Chicken Bowtie Pasta with Garlic Cheese Sauce is a must-try if you love spicy comfort food that doesn’t hold back on flavor. It’s easy enough for a Tuesday, delicious enough for a dinner party, and flexible enough to make it your own.

Whether you’re serving a hungry family or just need leftovers that actually excite you the next day, this dish hits the mark. So grab that skillet and get cooking!

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