Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

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Imagine a comforting plate of penne pasta coated in a creamy garlic parmesan sauce, topped with spiced Cajun chicken that adds just the right amount of heat. This dish brings together the richness of cheese and cream with the smoky kick of Cajun seasoning, creating a deeply satisfying dinner that’s perfect for cozy nights or impressing guests.

The creaminess of the sauce paired with the slight crunch of seared Cajun chicken creates a textural contrast that keeps every bite exciting. Whether you’re cooking for a family meal or a date night in, this dish delivers hearty flavor with a gourmet twist, all made with simple ingredients.

Why You’ll Love This Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

This recipe is pure comfort food with a flavorful upgrade. The Cajun-spiced chicken offers a bold punch that perfectly balances the velvety richness of the garlic parmesan sauce. It’s an easy dish that feels indulgent, yet comes together quickly on a weeknight.

The combination of textures—tender pasta, creamy sauce, and crispy, juicy chicken—makes every forkful feel special. Plus, it’s endlessly customizable: add veggies, swap proteins, or go gluten-free with alternative pasta.

What Kind of Pasta Works Best?

While penne is ideal for catching every bit of the luscious sauce in its ridges, you can absolutely switch it up. Rigatoni, fusilli, or even fettuccine will soak up that garlic parmesan goodness beautifully. Just aim for a shape that holds the sauce well and has a bit of bite when cooked al dente.

Ingredients for the Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

This recipe combines robust Cajun spices with a creamy, cheesy sauce that clings to every bite of penne. To bring it all together, here are the simple yet flavorful ingredients you’ll need:

• Penne pasta
• Chicken breast
• Cajun seasoning
• Olive oil
• Butter
• Garlic
• Heavy cream
• Parmesan cheese
• Salt and pepper
• Fresh parsley

Each of these plays a vital role: penne pasta holds the sauce well; chicken breast gives the dish its hearty protein base; Cajun seasoning infuses bold flavor; olive oil and butter provide the richness to sear and flavor; garlic sets a fragrant foundation; heavy cream and parmesan cheese create the luscious cream sauce; and salt, pepper, and parsley balance and finish the dish.

How To Make the Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

Step 1: Cook the Pasta

Boil the penne pasta in salted water until al dente. Drain and set aside, reserving a bit of pasta water.

Step 2: Season and Sear the Chicken

Coat the chicken breast in Cajun seasoning. In a skillet over medium-high heat, warm olive oil and sear the chicken on both sides until golden and fully cooked. Remove from the pan and let rest before slicing.

Step 3: Build the Garlic Parmesan Sauce

Lower the heat to medium, add butter to the same pan, then sauté garlic until fragrant. Stir in heavy cream and simmer gently. Slowly add parmesan cheese, stirring until smooth. Season with salt and pepper to taste.

Step 4: Combine Everything

Return the penne to the skillet, tossing to coat in the creamy sauce. Add a splash of pasta water if needed to loosen the sauce. Nestle in the sliced Cajun chicken and heat everything through.

Step 5: Garnish and Serve

Top with chopped fresh parsley and extra parmesan if desired. Serve hot and enjoy immediately.

How to Serve and Store Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream

This creamy pasta dish serves up to 4 people, making it a perfect choice for family dinner or a cozy meal with friends. When serving, spoon generous portions into shallow bowls to showcase the creamy sauce and juicy chicken slices. A sprinkle of fresh parsley and extra parmesan brings a lovely final touch.

If you have leftovers, store them in an airtight container in the fridge for up to 3 days. Reheat gently on the stove or in the microwave with a splash of cream or milk to restore the saucy texture.

What to Serve With Cheesy Penne and Cajun Chicken?

Garlic Bread

A warm, buttery side of garlic bread is the perfect partner to soak up every drop of sauce.

Caesar Salad

The crispness of romaine and the tang of Caesar dressing balance the richness of the pasta.

Roasted Broccoli

A touch of charred greens adds freshness and complements the Cajun spices beautifully.

Sauteed Spinach

Lightly wilted spinach with a bit of garlic makes for a quick and healthy side.

Caprese Salad

Slices of fresh mozzarella, tomatoes, and basil offer a cool contrast to the warm pasta.

Creamy Corn Dip

If you’re serving a larger spread, this dish can act as a creamy companion.

Lemon Butter Asparagus

The citrus brightness of asparagus cuts through the richness of the cream sauce.

Balsamic Glazed Carrots

Sweet, tangy, and tender—these carrots balance the savory depth of the chicken and cheese.

Want More Pasta Ideas?

If you’re loving the cheesy richness and bold Cajun flavor, here are more pasta recipes that hit the same comforting notes:

• Creamy Cajun Linguine brings spicy heat with a luscious creamy finish.
• One Pot Creamy Cajun Sausage Pasta keeps it simple and bold in a single skillet.
• Cheesy Baked Ziti is bubbling with gooey cheese and baked perfection.
• Cheesy Beef Enchilada Tortellini adds a zesty Mexican twist to a comforting pasta favorite.
• Creamy Chicken and Broccoli blends wholesome greens with tender bites in a creamy sauce.

Save This Recipe For Later

📌 Save this recipe to your Pinterest dinner board so you can come back to it any time.

And let me know in the comments how yours turned out. Did you go heavy on the Cajun spice or keep it mild? Did you add any veggies or make it just the classic way?

I always enjoy hearing your takes on these meals. Your questions are welcome, too—let’s help each other keep dinner exciting.

Explore beautifully curated health-boosting meals on Zoe Recipes on Pinterest and discover your new go-to comfort food.

Conclusion

Cheesy Penne and Cajun Chicken in Garlic Parmesan Cream is a one-skillet comfort dish with a big personality. The spicy seared chicken, creamy sauce, and perfectly cooked pasta come together in a way that feels special yet simple. Try it once, and it might just become a regular in your dinner rotation.

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