Name: Chicken Pot Pie Casserole
Prep time: 10 min
Cook time: 30 min
Total time: 40 min
Cuisine: American
Ingredients: 2 cups cooked chicken; 1 ½ cups frozen mixed vegetables; 1 can (10.5 oz) cream of chicken soup; ½ cup sour cream; ½ teaspoon salt; ½ teaspoon black pepper; ½ teaspoon garlic powder; 1 cup shredded cheddar cheese (optional); 1 can refrigerated biscuit dough

Chicken Pot Pie Casserole brings all the cozy comfort of a classic pot pie in an easy, family-friendly format. With a creamy chicken filling tucked under a golden, buttery crust, this dish is perfect for busy weeknights when you still want something hearty and homemade. It captures the flavors of slow-cooked comfort food but bakes up in just a fraction of the time.

What makes this version especially delightful is the combination of crisp topping and rich, savory filling that melds beautifully with tender chicken and colorful vegetables. It’s the kind of meal that fills your kitchen with mouthwatering aroma and keeps everyone at the table coming back for seconds.

Why You’ll Love This Chicken Pot Pie Casserole

You’ll love this dish for its balance of simplicity and satisfaction. It uses ingredients you likely already have on hand, and it’s easy to prepare ahead or freeze for later. The creamy sauce, flaky crust, and warm filling are irresistible. It also makes great leftovers—if any remain!

What Kind of Crust Should I Use?

While traditional pot pies use pastry crusts, this casserole is more forgiving and flexible. You can use refrigerated biscuit dough, crescent roll sheets, or even puff pastry for a more elegant touch. The key is to choose something that will bake up golden and slightly crisp, providing that satisfying contrast to the creamy filling below.

Ingredients for the Chicken Pot Pie Casserole

To bring this comforting casserole together, you’ll need a few pantry staples and some flexible ingredients. The beauty is in how these simple components create such rich flavor.

Cooked chicken – Whether you use rotisserie, leftovers, or poached chicken breasts, this is the protein foundation.
Mixed vegetables – A frozen blend of peas, carrots, and corn adds texture and color.
Cream of chicken soup – Acts as the creamy base, making the filling rich and flavorful.
Sour cream – Adds a little tang and creaminess to the filling.
Salt and pepper – Simple but essential for seasoning.
Garlic powder – A subtle boost that enhances the savory notes.
Cheddar cheese – Optional, but it melts into the filling and adds a cozy layer of richness.
Refrigerated biscuit dough – Topping the casserole, these bake up golden brown and fluffy.

How To Make the Chicken Pot Pie Casserole

Step 1: Prep the Filling

In a large mixing bowl, combine cooked chicken, mixed vegetables, cream of chicken soup, sour cream, seasonings, and cheddar cheese (if using). Stir everything until it’s well coated and smooth.

Step 2: Fill the Dish

Transfer the mixture into a greased baking dish, spreading it evenly. This helps the biscuits cook consistently on top.

Step 3: Top with Biscuits

Place pieces of biscuit dough over the filling. You can keep them whole or cut them into smaller chunks for better coverage and crispness.

Step 4: Bake to Golden Perfection

Bake in a preheated oven at 375°F for about 25 to 30 minutes. The biscuits should puff up and turn golden brown while the filling bubbles underneath.

Step 5: Rest and Serve

Let the casserole sit for 5 minutes before serving. This helps everything set up slightly so it scoops beautifully onto plates.

How to Serve and Store This Casserole

This dish serves about 6 to 8 people, depending on portion size. It’s ideal for weeknight dinners, potlucks, or cozy weekend meals. If you have leftovers, they store well in an airtight container in the fridge for up to 4 days. Reheat in the oven or microwave until hot.

If you’re planning to freeze, assemble the filling and freeze it separately. Add fresh biscuits before baking for best texture.

What to Serve With Chicken Pot Pie Casserole?

Steamed Green Beans

Their crisp freshness balances the richness of the casserole.

Garden Salad

A simple vinaigrette-dressed salad adds a bright note.

Garlic Mashed Potatoes

Because more comfort food is always a good idea.

Roasted Brussels Sprouts

The caramelized edges bring in a welcome bitter contrast.

Apple Cranberry Slaw

A tart, crunchy slaw pairs well with the creamy dish.

Cornbread Muffins

Sweet and savory, these round out the Southern-style comfort.

Sautéed Mushrooms

Their earthy depth enhances the umami in the casserole.

Fruit Salad

A fresh and juicy finish that cleanses the palate.

Want More Chicken Casserole Ideas?

If you loved this Chicken Pot Pie Casserole, check out more comforting chicken-based dishes from Zoe:

Try the rich and creamy Creamy Chicken and Broccoli, a one-dish wonder perfect for busy nights.
For a crispy twist, you’ll love Crispy Buttered Ranch Chicken.
Enjoy a cheesy, savory spin with Cheesy Beef Enchilada Tortellini.
Craving lighter flavors? Lemon Garlic Butter Chicken Parmesan Linguine brings a zesty upgrade.

Save This Recipe For Later

📌 Save this recipe to your Pinterest comfort food board so you can come back to it whenever the craving hits.

Let me know in the comments how you made it your own. Did you add herbs, extra veggies, or switch up the crust?

I love hearing your creative twists on classics. If you have any questions, drop them below!

Explore beautifully curated comfort meals and more on Zoe Recipes on Pinterest and discover new favorites to make your meals memorable.

Conclusion

Chicken Pot Pie Casserole is a heartwarming, satisfying dish that combines convenience with comfort. It’s simple to prepare, endlessly customizable, and always a hit around the dinner table. Whether you’re feeding a crowd or meal-prepping for the week, it’s a must-try for any home cook who loves big flavor with little fuss.